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The result is selective apoptosis of FOXO4-high senescent cells, leaving FOXO4-low non-senescent cells intact a selectivity that makes it a uniquely powerful molecular probe for studying the contribution of senescent cell accumulation to tissue dysfunction, ageing phenotypes, and disease biology

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"Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB -dependent transcription of Wnt-2." Neuron 50(6): 897-909